Manufacturing Microbiome Therapeutics: Working with Living, Complex Products

Microbiome therapeutics present manufacturing challenges that differ from those associated with many conventional pharmaceutical products. Many contain living microorganisms or complex microbial communities, meaning factors such as viability, biological variability, processing conditions and storage must be considered throughout manufacture. These considerations apply across the microbiome therapeutics field, from defined live biotherapeutic products (LBPs) to complex […]

Understanding FMT Regulation

As interest in microbiome therapeutics continues to grow, discussions often focus on scientific discoveries, clinical research and emerging treatment approaches. However, one of the most important factors supporting the responsible development of the field is regulation. From faecal microbiota transplantation (FMT) to next generation microbiome therapeutics, regulatory frameworks play a fundamental role in helping ensure […]

Why Donor Screening and Standardisation Matter in Faecal Microbiota Transplantation (FMT)

Introduction Faecal microbiota transplantation (FMT) involves transferring gut bacteria from a healthy donor to a recipient to help restore microbiome balance. As interest in microbiome-based therapies has increased, so too has the focus on the quality, safety and consistency of FMT preparations. The quality of any FMT preparation begins with the donor material. Robust donor […]

The Gut Microbiome and Mental Health: Understanding a Complex Relationship

May 2026 Mental health is shaped by a combination of psychological, social, and biological factors. In recent years, the gut microbiome has become an area of growing scientific interest within this broader context. Research into the gut microbiome and mental health has expanded significantly in recent years, reflecting growing interest in how biological systems interact […]

Gut Pathogens and the Microbiome: Causes, Impact and Management

The human gut is home to a complex and dynamic microbial ecosystem that plays a fundamental role in digestion, immune function, and overall health. Beyond these functions, the gut microbiome also acts as a critical line of defence against the colonisation of potentially harmful microorganisms. When this balance is disrupted, the gastrointestinal environment can become […]

Faecal Microbiota Transplantation (FMT): Past, Present, and Future

Over the past decade, interest in the human gut microbiome has accelerated dramatically, transforming how researchers and clinicians understand the relationship between microbial ecosystems and human health. At the centre of this scientific shift is Faecal Microbiota Transplantation (FMT), a therapy that aims to restore microbial balance through the transfer of beneficial donor microorganisms. As […]